Why take TMG With NMN Supplement
- ETS
- Sep 2, 2024
- 1 min read

Taking TMG (Trimethylglycine) with NMN (Nicotinamide Mononucleotide) is a common practice among those interested in longevity and health supplements. The combination is often recommended for the following reasons:
Methylation Support: NMN is a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme involved in many cellular processes, including energy production and DNA repair. However, the process of increasing NAD+ levels with NMN can also increase the demand for methyl groups in the body. TMG acts as a methyl donor, which helps support healthy methylation and reduces the potential depletion of methyl groups.
Homocysteine Regulation: TMG is also known for its ability to lower homocysteine levels. Elevated homocysteine is associated with cardiovascular issues. By taking TMG, you help ensure that homocysteine levels remain in check while you take NMN.
Synergistic Effects: Some believe that the combination of NMN and TMG might have synergistic effects, enhancing the overall benefits for cellular health, energy metabolism, and longevity.
Prevention of Side Effects: Some users report side effects like fatigue when taking NMN alone, possibly due to a lack of sufficient methyl donors in their system. Adding TMG can help mitigate these side effects.
Overall, the combination of TMG with NMN is aimed at optimizing the benefits of NMN supplementation while supporting the body's methylation processes and reducing potential side effects.
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